Kisplyx -Keytruda Continues to Show Benefit in Advanced Kidney Cancer

The drug duo Kisplyx plus Keytruda led to improved outcomes for patients with advanced renal cell carcinoma, extended follow-up of the CLEAR trial showed.

Kisplyx (lenvatinib) plus Keytruda (pembrolizumab) improved outcomes in patients with advanced renal cell carcinoma — the most common type of kidney cancer — compared to those treated with Sutent (sunitinib), according to extended follow-up from the randomized, phase 3 CLEAR trial, which was published in the Lancet Oncology.

The trial, which included 1,417 patients with clear-cell advanced renal cell carcinoma who previously did not have any medication for the disease, randomly assigned participants to one of three groups:

• Kisplyx plus Keytruda
• Kisplyx plus Afinitor (everolimus)
• Sutent

Patients in the Kisplyx /Keytruda group lived for an average of 27.8 months without their disease getting worse (a metric known as “progression-free survival”), compared to 19.4 months for patients in the Sutent group.

Of note, results from the Kisplyx /Afinitor group were not included in the updated analysis.

Average overall survival, which is the time from treatment until death of any cause, was 33.7 months in the Kisplyx plus Keytruda group, compared with 33.4 months in the Sutent group.

These data are consistent with prior results from CLEAR that were presented at the American Society of Clinical Oncology Annual Meeting in June 2022, which showed that at the 24-month mark, 72.2% of patients given Kisplyx plus Keytruda were alive on their second line of treatment, compared with 54.2% in the Sutent group.

Read the full article on Curetoday.com