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Pexa-Vec with immunotherapy reduced tumor in 75% of RCC patients

by | Apr 29, 2020 | Kidney Cancer News

San Francisco based SillaJen Biotherapeutics said a combination of its oncolytic viral therapy Pexa-Vec (JX-594) with immune check inhibitor Libtayo (ingredient: cemiplimab) has reduced tumor in 12 out of 16 kidney cancer patients. It also shrank the size of the tumor more than 30 percent in nine out of the 12 patients, the company added.
The company released the interim results of the Phase-1b trial at the meeting of the American Association for Cancer Research (AACR) on Monday.
Twelve out of the 16 patients available for analysis had a 75 percent disease control rate (DCR), which combined complete response (CR), partial response (PR), and stable disease (SD). More specifically, one showed CR, and five, PR. Six had SD without cancer progression, and four, progressive disease (PD) with cancer progression.
In total, 12 out of 16 patients had tumor size reduction, and nine among them had more than 30 percent tumor burden reduction. However, three patients had either progressive or stable disease because new lesions appeared.
In terms of safety, 5.7 percent of patients showed severe adverse reactions of Grade 3 or higher. Most of the other adverse reactions were mild side effects such as fever immediately after a drug administration and a temporary increase in blood pressure.
Even though the study did not directly compare the combined therapy with Libtayo alone, the combo could be effective given the immunotherapy’s low response rate at around 20 percent, the company said.
© Korea Biomedical Review.
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<a href="" target="_self">Malcolm Packer</a>

Malcolm Packer

Malcolm is Chief Executive Officer at Kidney Cancer UK and Kidney Cancer Scotland and has worked with the charity in various capacities for over 15 years.