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Sunitinib (Sutent) is a targeted therapy used to treat renal cell carcinoma in the kidney, gastrointestinal stromal tumours (GISTs) and pancreatic neuroendocrine tumours. It may be used in research trials for other cancers too. It works by blocking (inhibiting) signals in the cancer cells that make them grow. Blocking the signals causes the cells to die. Sunitinib can also stop cancer cells from developing new blood vessels. This reduces their supply of oxygen and nutrients so the tumour shrinks or stops growing. Drugs that interfere with blood vessel growth are called angiogenesis inhibitors or anti-angiogenics.